Answer to Question #189959 in Molecular Biology for Naveed Ahmad

Question

A terminator acts as a termination signal in the process of transcription, whereas termination of translation is brought about by a stop codon. How the terminator and stop codon differ from each other with regards to ending the process in which they are involved? Give an answer comprising at most 2 sentences.

Answer 1

In case of termination of replication the two replication forks of E.coli meet at terminus (Ter) region, The terminal utilization proteins (Tus) binds at the ter region and forms a Tus-Ter complex. The complex stops the two replication fork upon completion of two interlinked DNA in E.coli. After which the DNA topo isomerase A acts on the catenated circular DNA and separates the two replicated DNA.

In case of eukaryotes multiple replication forks are formed in the chromosome, The termination occurs when two replication fork meets. At the end of the chromosome telomerase act upon and synthesize repeated units of telomeres. Telomeres extend the 3' end of the parental chromosome beyond the 5' end of the daughter strand. The single-stranded DNA recruits telomerase. Telomerase contains a protein subunit that is a reverse transcriptase called telomerase reverse transcriptase or TERT. TERT synthesizes DNA until the end of the template telomerase RNA and then disengages.