Answer to Question #161035 in Microbiology for Virat

Question #161035

In the histologic specimen of loose irregular fibrous connective tissue stained with methyl blue pyronin one can see that some cells contain pyroninophilic cytoplasm, and close to the nucleus in each of the cells there is clearing? What do we call those cells? What function does it perform?

Expert's answer

The only cells containing pyroninophilic cytoplasm are plasma cells. They are not part of the loose connective tissue, but they are found mostly alongside the Reticular connective tissue,

a delicate network of interwoven fibers with reticular cells (like fibroblasts), that forms stroma (internal framework) of organs. It is located in the lymph nodes, spleen, and bone marrow.

The plasma cells mentioned above play a significant role in adaptive immune response, hence responsible for humoral immunity.

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