Answer on Biochemistry Question for Sanjukta Ghosh
My question is are the two electrons and protons needed for reduction of FAD provided by Acyl CoA for Acyl CoA can only loose a H- and a H+ to become unsaturated, Trans-delta2-enoyl CoA,?
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I got it Thank you.
Though FAD reduction requires two electrons and protons, only one electron and one proton are accepted by FAD. Acyl-CoA loses two protons and electrons. This is a two step reaction. The first hydrogen being removed by the active center base Glu376-COO- (Acyl-CoA dehydrogenase) as a H+. The second proton is then transferred as a hydride (H-) to the flavin N(5) position. Now, Acyl-Coa becomes unsaturated. FAD gets its seconf proton from the active center of Acyl-CoA dehydrogenase and becomes reduced to FADH2.
But are the two electrons and protons needed for reduction of FAD provided by Acyl CoA ? Where does the 2nd electron come from as Acyl CoA can only looses a H- and a H+ to become unsaturated, Trans-delta2-enoyl CoA.