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Eukaryotic DNA topoisomerases are an enzymes that act to relax supercoils generated during transcription and DNA replication. Because of the size of the eukaryotic chromosome, removal of these supercoils can only be accomplished locally by introducing breaks into the DNA helix. Topo I mediates DNA relaxation by creating a transient single-strand break in the DNA duplex. Type II topoisomerases cut both strands of the DNA helix simultaneously. These transient nicks allows the broken strand to rotate around its intact complement, effectively removing local supercoils. Thus, the correct answer is C
A. Both A and R are true and R is the correct explanation of A. B. Both A and R are true but R is NOT the correct explanation of A. C. A is true but R is false. D. Both A and R are false.