If a patient had a mutation in the insulin receptor which caused them to make TOO much insulin receptor, which would you expect?
Anunexpected observation was the ability of mitogens, such as concanavalin A and Epstein-Barr virus, to increase expression of insulin receptors (IRs) in lymphocytes. Moreover, human lymphocyte-derived malignant cells, such as the IM-9 cells (B-type lymphoblasts derived from a subject with multiple myeloma), are abundantly endowed with high-affinity IRs. IR up-regulation in these cells has no major effect on cell metabolism, but coincides with the development of increased sensitivity to the nonmetabolic effects of insulin. A role for IR in tumor progression was suggested by studies indicating that IR is overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.
It’s obvious to say that our standards and expectations of living and working has changed drastically since the global pandemic…
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I want to sincerely thank you for your help. your work and time that it was completed are more than I could have hoped for and I appreciate your efforts. I look forward to working with you on the next project. which will be in a few months.