Answer to Question #213847 in Cell Biology for lala

Question #213847

In what way that DNA replication in E. coli shares the profound common ground with DNA replication in human?

Expert's answer

E. coli, as most microscopic organisms (bacteria), has a single origin of replication on its chromosome. As the DNA opens, two Y-molded designs called replication forks are framed, together making up what's known as a replication bubble. The replication forks will move in inverse ways as replication continues. 

In humans, in excess of 6 billion bp of DNA should be replicated precisely and totally every cell division. Given the size of human chromosomes, it's anything but a couple of bidirectional DNA replication forks, radiating from a single replication origin, over 40 days to duplicate just chromosome 1.

DNA replication is semiconservative. Each strand in the double helix goes about as a template for amalgamation of another, integral strand. New DNA is made by enzymes called DNA polymerases, which require a layout and a primer (starter) and synthesise DNA in the 5' to 3' direction.

 DNA replication is simply the interaction by which the DNA copies itself. It is semi-conservative and bidirectional in nature. DNA replication is semiconservative on the grounds that out of two strands of the daughter DNA one comes from the parent DNA which is otherwise called the template strand. Toward the beginning of the DNA replication, the hydrogen bonds between the nucleotides of two strands break by the activity of enzyme helicase. DNA replication is bidirectional on the grounds that it happens in 5'- 3' and 3'- 5' course. The DNA is combined by DNA polymerase in the 5'- 3' heading on leading strand by DNA polymerase. At the point when the DNA polymerase works the other way on lagging strand it blends discontinuous short DNA portions known as Okazaki in 3'- 5' direction.

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