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Answer to Question #33803 in Biochemistry for Sumit

Question #33803
An enzyme completely complementary to its substrate would be a very poor enzyme. - Explain why?
Expert's answer
Such an enzyme impedes the reaction, stabilizing the substrate instead. When the enzyme is complementary to the substrate the ES(enzyme-substrate) complex is more stable and has less free energy in theground state than substrate alone. The result is an increase in the activation energy.

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