If the kinetic parameters of the uninhibited Cytochrome P450 3A4 are; KM = 2.36 µM and Vmax = 3.87 pM/min and the inhibition constant of fluconazole for Cytochrome P450 3A4 is KI = 9.21 µM, how much slower is the initial reaction rate of the break-down of Compound X (MW 300g/mol) (blood concentration: 6 µg/ml) by Cytochrome P450 3A4 in the presence of Fluconazole (blood concentration: 5 µg/ml)?
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2018-10-23T09:38:18-0400
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