Answer to Question #82252 in Chemistry for Zi

Question

If the kinetic parameters of the uninhibited Cytochrome P450 3A4 are; KM = 2.36 µM and Vmax = 3.87 pM/min and the inhibition constant of fluconazole for Cytochrome P450 3A4 is KI = 9.21 µM, how much slower is the initial reaction rate of the break-down of Compound X (MW 300g/mol) (blood concentration: 6 µg/ml) by Cytochrome P450 3A4 in the presence of Fluconazole (blood concentration: 5 µg/ml)?

Answer 1

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