Answer to Question #99127 in Organic Chemistry for S

Question

What is the retrosynthetic analysis of estrone?

Answer 1

The structures of several estranes are established by x-ray crustal structure measurements in combination of their NMR spectroscopic data and correlation with literature precedent. The estranes are captured in a retrosynthetic manner into scheme 1 where the 13-endotrig macrocyclization radical cascade from the iodopolyene precursor 8 and iodovinylcylopropane 10 in scheme 2. These investigations are brought together to analyse estrone