Answer to Question #85658 in Organic Chemistry for Abdu

Question #85658
An aminoacid has pk1-2 pk2-3.5 pk3-6.3
pk4-8 pk5-9.2 pk6-10.4
How to know the isoelectric pH
And how many acidic and basic functional groups are there?
Expert's answer

There are three acidic functional groups which have pK<7 : pK1= 2, pK2 = 3.4, pK3 = 6.3

There are three basic functional gruops whcih have pK>7: pK4 = 8, pK5 = 9.2, pK6 = 10.4

Isoelectric point (pI) is the pH at which an aminoacid is electrically neutral (i.e. exists in the form of zwitterion). To calculate pI we need to average the pKa values relevant to the protonation/deprotonation of the form with no net charge.

The Form IV has net charge = 0, then pI = (pK3 +pK4)/2 = (6.3+8)/2=7.15

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