Answer to Question #83922 in Organic Chemistry for Chirag S.Contractor

Question

Dear friends may I know an appropriate route of synthesis of 2-amino-5-methoxy benzenesulfonic acid?

Answer 1

Synthesis method of 2-amino-5-methoxybenzene sulfonic acid:

1) 2H2SO4 and sodium nitrate are added into phenol to generate p-nitrophenol;

2) then, zinc powder and hydrochloric acid are added; p-aminophenol is further generated;

3) then, concentrated sulfuric acid and an Aladdin reagent are dropwise added into the aminophenol; 2-amino-5-hydroxybenzene sulfonic acid is obtained after the reaction;

4)then, a sodium hydroxide solution is added to generate 2-amino-5-sodium epoxide phenol sodium;

5) finally, a CH3I solution is added into the 2-amino-5-sodium epoxide phenol sodium;

6) after the 2-amino-5-sodium epoxide phenol sodium is generated, a H2SO4 solution is added at high temperature; the 2-amino-5-methoxybenzene sulfonic acid is generated.

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