Currently, the main use for LDH is as a general indicator of the existence and severity of acute
tissue damage and, sometimes, as a monitor of progressive conditions such as some cancers, kidney disease
, and liver disease
. It used to be ordered to help diagnose and monitor a heart attack
, but the troponin test
has largely replaced LDH in this role. LDH isoenzymes may be used in differential diagnosis to help determine which organs are likely to be involved.