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Answer to Question #53367 in Organic Chemistry for manisha

Question #53367
Explain Hoffman's ammonolysis reaction.and also tell that how this reaction occur?
Expert's answer
Since alkyl halides have positive charge on the carbon connected with Halogen they undergo nucleophilic substitution with NH3 which has a lone pair.
R-X + NH3 → R-NH2 + HX, where R-alkyl and X-halogen.
In case of excess of alkyl halide the reaction goes further to produce other amines:
R-NH2 + R-X → R2NH + HX (secondary amine)
R2NH + R-X → R3N + HX (tertiary amine)
R3N + R-X → R4N+X- (quaternary ammonium salt)

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