Answer to Question #205153 in Organic Chemistry for Faye Liew

Question

How can a gitalin be synthesised using reagents?

I could only found biosynthesis of gitalin rather than chemical synthesis.Biosynthesis involves enzymatic reaction. However, I wish to know how is gitalin synthesised using reagents?

Answer 1

Organic reagent, 4-(6-Bromo-2-Benzothiazolylazo) pyrogallol (4-Br-BTAP), was synthesized by coupling reaction of diazotized 2-amino-6-bromobenzothiazole with pyrogallol and purified using ethanol recrystallization method. Analysis and characterization of synthesized product were carried out using melting point, elementary analysis, IR and H¹-NMR. Dissociation constants of the organic reagent were calculated by spectrophotometric method. Absorption spectra of the 4-Br-BTAP in solvents of different polarities were investigated. Analytical application of 4-Br-BTAP was established with Cu (II) and Pd (II).

Biosynthesis occurs due to a series of chemical reactions. ... Precursor compounds: these compounds are the starting molecules or substrates in a reaction.