Link to Remdesivir structure: (pls see second figure on the website):
Reactions that are difficult to control, with hazardous reagents and/or intermediate species, are usually carried out in a controlled manner by working with small amounts. This becomes an apparent problem when the process is scaled up in batch as it requires greater amounts of hazardous reagents and a greater capacity for the cooling or heating a large vessel.
“For this reason Vieira et al looked at translating the process into a flow regime. With a much smaller reactor volume and the inherent ability of flow chemistry systems to deliver improved temperature control and mixing, this reaction was successfully carried out using our R-Series system.