Answer to Question #190592 in Organic Chemistry for Alex

Question

Link to Remdesivir structure: (pls see second figure on the website):

https://www.asbmb.org/asbmb-today/science/031720/what-makes-remdesivir-a-promising-antiviral

1. On the skeletal structure above (see link below), encircle and name the key functional groups.
2. Describe the polarity of each functional group, and the overall solubility of the molecule in water and hexane. Indicate what kind of IMF interactions are expected for each functional group with the solvent.
3. Are there functional groups which can gain or lose H ? Which ones? If so, how will this affect solubility?

Answer 1

Reactions that are difficult to control, with hazardous reagents and/or intermediate species, are usually carried out in a controlled manner by working with small amounts. This becomes an apparent problem when the process is scaled up in batch as it requires greater amounts of hazardous reagents and a greater capacity for the cooling or heating a large vessel.

“For this reason Vieira et al looked at translating the process into a flow regime. With a much smaller reactor volume and the inherent ability of flow chemistry systems to deliver improved temperature control and mixing, this reaction was successfully carried out using our R-Series system.