Answer to Question #190424 in Organic Chemistry for hevi

Question

Analyse the effects of different monosubstituents on the benzene ring to predict further substitution position(s) of a reaction species on the benzene ring. 

Answer 1

Experiments have shown that substituents on a benzene ring can influence reactivity in a profound manner. For example, a hydroxy or methoxy substituent increases the rate of electrophilic substitution about ten thousand fold, as illustrated by the case of anisole in the virtual demonstration.