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Answer on Organic Chemistry Question for Sean

Question #18043
I wanted to figure out how to attach a carbonyl group (either from an aldehyde or carboxylic acid) to the 3-position of indole. I may use a carboxy chloride. Since indole has 2 aromatic rings, there are several carbons available for attachment, and the carbonyl group might randomly become attached to any one of them, from what I understand. So my question pertains to specificity. How do I make sure it specifically attaches to the 3-position?
Expert's answer

Indole is a π-excessive heterocycle, therefore it is subjected to ready electrophilic substitution and C3 is the preferred site for electrophilic attack.

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