Answer to Question #128555 in Organic Chemistry for Kamli Ramli

Question

Why quinoline is used as solvent in decarboxylation reaction?

Answer 1

1) Quinoline act as nucleophile toward the carboxyl carbon.

2) Quinoline can provide high reaction temperatures which are often required for the decarboxylation.

3) Quinoline is a base andt herefore is able to facilitate proton transfer by accepting a proton from the carboxyl group;