Answer to Question #205722 in Inorganic Chemistry for Maria

Question

One specific application for non aqueous titration from pharmacopeia. The application should show the reactions taking place and technique of determination of end point.

Answer 1

Non aqueous titration may be used to determine the percentage purity of weak bases or weak acid drugs. Such drugs include H1 Antihistamines such as LOR.

Amphiprotic solvents are used to act as a medium. CH₃COOH forms an onium ion intermediary with HClO₄ which readily donates a proton to LOR.The endpoint is determined by potentiometry or using indicators such as crystal violate.