Answer to Question #154976 in Inorganic Chemistry for mary

Question #154976

what is the geometry around each central atom in dimethyl fumarate



1
Expert's answer
2021-01-15T06:26:14-0500

Based on a resolution crystal structure of the C-terminal kinase domain of the mouse p Ribosomal S Kinase (RSK2) inhibited by DMF we describe a central binding site in RSKs and the closely related Mitogen and Stress-activated Kinases (MSKs).

Binding of DMF prevents the activation loop of the kinase from engaging substrate, and stabilizes an auto-inhibitory αL-helix, thus pointing to an effective, allosteric mechanism of kinase inhibition.



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