Answer to Question #226193 in General Chemistry for Amrutha

Question

Can NH2 be conjugated to carbonyl C=O group? It’s not a carboxylic group rather a carbonyl group. Can we used EDC-NHS for that

Answer 1

Yes. Conjugation of a double bond to a carbonyl group transmits the electrophilic character of the carbonyl carbon to the beta-carbon of the double bond. These conjugated carbonyl are called enones or α, β unsaturated carbonyls. A resonance description of this transmission is shown below..