Answer to Question #138802 in General Chemistry for Jay Riley

Question

Questions regarding an isothermal titration calorimeter:
1. Is it much like a coffee cup setup? Can it detect the heat absorbed or released from a chemical reaction?
2. Can it be used to heat and melt metals?
3. Can the instrument inject a small volume of reagent into the solution multiple times?

Answer 1

Isothermal titration calorimetry is a physical technique used to determine the thermodynamic parameters of interactions in solution.

It is most often used to study the binding of small molecules to larger macromolecules (like protein). In the shell where experiment sample present small molicules (ligand) are injected into it multiple times until large molicular get saturated.

So,

Correct questions regarding an isothermal titration calorimeter is.....

3. Can the instrument inject a small volume of reagent into the solution multiple times?