Answer to Question #128076 in General Chemistry for Assingee Ivy

Question

Chlorthiazide is an acidic drug with pka 8.41 and pyrimethamine is a base drug with pka 7.41even though both reactive centers are NH and NH2 groups. Assuming the drugs were individually formulated as oral dosage form. Which of the two drugs will have high bioavailability at phone 6.0.show all detailed calculation involved and state reasons for your answer.

Answer 1

The Ksp of MX = 9.06 x 10-5