Question #128076
Chlorthiazide is an acidic drug with pka 8.41 and pyrimethamine is a base drug with pka 7.41even though both reactive centers are NH and NH2 groups. Assuming the drugs were individually formulated as oral dosage form. Which of the two drugs will have high bioavailability at phone 6.0.show all detailed calculation involved and state reasons for your answer.
1
Expert's answer
2020-08-02T15:49:57-0400

The Ksp of MX = 9.06 x 10-5


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