Dengue virus has 4 different serotypes and each interact with the antibodies in the serum differently.So how does each of these serotype interact differently (with reference to immunology)
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Expert's answer
2018-07-03T05:07:35-0400
The difference between serotypes based on the difference of surface proteins - E protein. Recombinant domains of the E protein are used as antigens in the serological detection of antibodies and as immunogenes in serum. E domain of Dengue virus 1 interacts with murine antibody E111 and form the complex with its Fab and scFv fragments. E domain of Dengue virus 1, 2, 3 interact with murine antibody 1A1D-2 and form the complex with its Fab fragment.. The murine antibody 2H12 interacts with Dengue virus 1, 2, 4 by Fab fragment. The murine antibody 4E11 neutralizes all four DENV serotypes by scFv fragment. The chimpanzee antibody 5H2 neutralizes Dengue virus 4 by crystallization in complex. Also all four serotypes interacts with Fab or scFv fragments of the human antibodies Ede1-C10, Ede2-A11 and Ede2-B7. They interacts with E protein.
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