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Answer to Question #78767 in Other Biology for PRATYASHA MISHRA

Question #78767
Dengue virus has 4 different serotypes and each interact with the antibodies in the serum differently.So how does each of these serotype interact differently (with reference to immunology)
Expert's answer
The difference between serotypes based on the difference of surface proteins - E protein.
Recombinant domains of the E protein are used as antigens in the serological detection of
antibodies and as immunogenes in serum. E domain of Dengue virus 1 interacts with murine
antibody E111 and form the complex with its Fab and scFv fragments. E domain of Dengue
virus 1, 2, 3 interact with murine antibody 1A1D-2 and form the complex with its Fab
fragment.. The murine antibody 2H12 interacts with Dengue virus 1, 2, 4 by Fab fragment.
The murine antibody 4E11 neutralizes all four DENV serotypes by scFv fragment. The
chimpanzee antibody 5H2 neutralizes Dengue virus 4 by crystallization in complex. Also all
four serotypes interacts with Fab or scFv fragments of the human antibodies Ede1-C10,
Ede2-A11 and Ede2-B7. They interacts with E protein.

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