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Answer to Question #51113 in Other Biology for Sumit

Question #51113
An example of passive vaccination is when Rh- mothers carrying Rh+ babies are given Rho GAM, humanized antibodies against the Rh+ antigen. Explain why this vaccine does not trigger heme agglutination in the new born.
Expert's answer
This vaccine does not trigger heme agglutination in the newborn because it crosses placenta and causes destruction of Rh-positive erythrocytes of the newborn before the immune system of the mother recognize them. Activation of macrophages by coated with antibodies erythrocytes causes hemolysis in the spleen of baby.

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