Answer to Question #23605 in Other Biology for BIRHANU SIMON
On the contrary, some studies suggest that people who are slow acetylators are at greater risk, suggesting that slow metabolism results in& diversion of isoniazid metabolism to an alternate (eg, cytochrome P-450–mediated) pathway that may produce a toxic metabolite. This latter interpretation is supported by observations that drugs that induce cytochrome P-450 levels (including rifampin, which often is prescribed together with isoniazid) appear to increase the risk of isoniazid toxicity.
fast acetylators = drug resistance
slow acetylators = hepatotoxicity
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