Answer to Question #193904 in Biology for Mhlanga Gracious

Question #193904

n tabular form, compare the similarities and differences between Mycobacterium tuberculosis and Mycobacterium leprae in relation to morphology, transmission, pathogenesis, diagnosis and treatment:

Expert's answer

Mycobacterium tuberculosis:

  • morphology: bacilli;
  • transmission: through the air;
  • pathogenesis: invades macrophages, affects lungs and local lymph nodes ;
  • diagnosis: the Mantoux tuberculin skin, blood test, and a chest x-ray;
  • treatment: a combination of antibiotics (i.e., isoniazid, rifampin, ethambutol, and pyrazinamide).

Mycobacterium leprae:

  • morphology: bacilli;
  • transmission: probably, through direct contact (not known exactly);
  • pathogenesis: invades the Schwann cells of the peripheral nervous system, affects skin and nerves;
  • diagnosis: a skin biopsy and a lepromin skin test;
  • treatment: a combination of antibiotics (i.e., dapsone, rifampicin, and clofazimine).

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