Many medications can be administered transdermally by applying patches that contain the medication to the surface of the skin. These patches can be attached anywhere on the skin except the palms of the hands and the soles of the feet. Why?
It is on account of the fact that the skin in the areas of the palms of hands and the soles of feet is thicker than on other parts of your body and has a high density. So administering the medications in these areas may be inefficient.