Answer to Question #128898 in Biology for kylie

Question #128898
Discuss how proto-oncogenes become oncogenes.
1
Expert's answer
2020-08-19T06:23:53-0400

Mutation in the proto-oncogene gene or its promoter may lead to its overexpression or overactivation. For instance, gain-o-function mutation may lead to constitutive activation of a proto-oncogene leading to stimulation of cell cycle progression or suppression of the pro-apoptotic pathway. On the other hand, mutations in the proto-oncogene promoter may lead to overexpression of the gene also stimulation its functioning. in both cases, proto-oncogenes induce abnormal growth and proliferation of cells that cannot be inhibited by cellular tumor suppressors.


Need a fast expert's response?

Submit order

and get a quick answer at the best price

for any assignment or question with DETAILED EXPLANATIONS!

Comments

No comments. Be the first!

Leave a comment

Ask Your question

LATEST TUTORIALS
New on Blog
APPROVED BY CLIENTS