Answer to Question #63146 in Molecular Biology for Sanjukta Ghosh
What I understand of these two terms is that:
Paratope is a portion of antibody that recognises and binds to specific antigen.
Idiotype is an antigenic determinant of antibody formed of CDRs that have specificity for a particular epitope. Some authors call the antibodies recognising a particular epitope an idiotype.
Well the CDRs, they actually form the paratope so is it right to say the CDR that acts as an paratope also forms the idiotypic determinant/ idiotype ?
Therefore, paratope is the part of the idiotype that binds to the epitope.
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