Answer on Molecular Biology Question for Sanjukta Ghosh
Are inflammatory mediators released by Pattern recognition receptor containing cells, injured/infected cell/leukocyte or all there?
Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection in all cells is mediated by innate pattern recognition receptors (PRRs), which include Toll-like receptors, RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors. The intracellular signaling cascades triggered by these PRRs lead to transcriptional expression of inflammatory mediators that coordinate the elimination of pathogens and infected cells. However, aberrant activation of this system leads to immunodeficiency, septic shock, or induction of autoimmunity. Inflammatory mediators released by Pattern recognition receptor containing cells in all injured/infected cell/leukocyte.