Answer to Question #60403 in Molecular Biology for Sanjukta Ghosh

Question #60403
What are tertiary structure, motif and domain? I really don't understand these three terms. If you could explain with illustration it would be of great help. Some of my doubts: 'The overall 3D structure of the polypeptide chain is referred to as the protein's tertiary structure.' -All molecules have a 3D structure, even a linear polypeptide chain has a three dimensional structure so do alpha helix and beta pleated sheet,but here I don't understand what is meant by 'overall 3D structure', is it the 3D structure of an Alpha helix (when aprotein is formed of a single alpha helix)? A linear polypeptide (primary structure) through specific intra-chain H-bonding form alpha helix and beta pleated sheet(secondary structure), but how does the secondary structure contribute to tertiary structure? How is a motif different from tertiary structure? What is a domain actually?
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