Answer to Question #50778 in Molecular Biology for Spencer
What issues would you consider before embarking on a project using a clonal cell line model? What types of functions would be appropriated or inappropriate to study in such a system?
At first, how many passages could be done before these cells change some of their characteristics due to a mutation. Using this model you can investigate genomics, proteomics, cellular trafficking processes. Inappropriate could be the research of physiological functions, cell to cell communications.