Answer to Question #26979 in Molecular Biology for fatima
There is a genetic polymorphism in the acetylation of isonaizid, the major mechanism for its inactivation. Some individuals are rapid inactivators, some are slow, and the rest are intermediate. Marked differences are found among global populations. For Europeans and blacks, about half are slow inactivators, but among several Asian populations, the prevalence of the allele for rapid inactivation is close to 70%. Which one of the following is the best approach for drug management of this antituberculous drug?
a. Test members of the Asian races for rapid activators and use a drug regimen with higher doses given more rapidly.
b. Use the usual recommended dose schedule since there is no mention of problems with rapid acetylators in the information sheet provided by the manufacturer.
c. Use a different antituberculous drug for Asians even though it may not be quite as effective or as free of complications as iso