Answer to Question #23207 in Molecular Biology for Karim

Question

What are local and non-local interaction in protein folding?

Answer 1

Here are two types of non-covalent interaction in proteins: local and non-local, so defined in terms of the distance in the sequence between the interacting residues. Importantly, they are geometrically different; local interactions participate in defining secondary structure while non-local interactions are involved in defining the tertiary structure.