5. Familial breast cancer and ovarian cancer (BC) are diagnosed in almost every 10th woman in Europe. Approximately 5-10% of breast cancer is hereditary. Mapped and identified two genes - oncosuppressor –BRCA –1 and BRCA – 2, mutations in which are the cause of familial breast cancer and ovaries. In which human chromosome are the BRCA – 1 and BRCA – 2 genes localized?
- Complete the quest with:
· · Online Mendelian Inheritance in Man (OMIM)
· Human Genome Mutation Database (HGMD)
BRCA1 genes are located on chromosome number 17 while BRCA2 genes are located on chromosome 13.