Answer to Question #216788 in Microbiology for Nizba

Question #216788

describe activation of CD4 helper T cells by interaction of the TCR with peptide fragments presented by class II MHC molecules on APCs


1
Expert's answer
2021-07-14T07:36:02-0400

The T cell receptor (TCR) on both CD4+ helper T cells and CD8+ cytotoxic T cells binds to the antigen as it is held in a structure called the MHC complex, on the surface of the APC. This triggers initial activation of the T cells. The CD4 and CD8 molecules then bind to the MHC molecule too, stabilizing the whole structure. This initial binding between a T cell specific for one antigen and the antigen-MHC it matches sets the whole response in motion.


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