58 626
Assignments Done
Successfully Done
In March 2018
Your physics homework can be a real challenge, and the due date can be really close — feel free to use our assistance and get the desired result.
Be sure that math assignments completed by our experts will be error-free and done according to your instructions specified in the submitted order form.
Our experts will gladly share their knowledge and help you with programming homework. Keep up with the world’s newest programming trends.

Answer on Genetics Question for Sanjukta Ghosh

Question #65438
This could fall under Molecular biology too.

Why does increase in age of the mother increases the chance of having an offspring with Down Syndrome?

I want to know the molecular basis of this observation.
Expert's answer
There is a lot of chromosomal abnormalities that may cause Down syndrome, but only non-disjunction of sister chromatids is associated with the maternal age. Although the molecular reasons for this observation are not absolutely clear; it is speculated that with the course of the time oocytes suffer from multiple molecular abnormalities: non-separating cohesins, pathologic SAC proteins (spindle assembly checkpoint), malformations in the synaptonemal complex and even epigenetic changes.

Source: Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew. Curr Opin Pediatr. 2009 Dec; 21(6): 703–708. doi: 10.1097/MOP.0b013e328332c6ab

Need a fast expert's response?

Submit order

and get a quick answer at the best price

for any assignment or question with DETAILED EXPLANATIONS!


No comments. Be first!

Leave a comment

Ask Your question