What is the accepted method for proving that cells derived from bone marrow are true HSCs? Briefly describe the method.
Standard method for proving that cells derived from bone marrow are true HSCs is based largely on animal models of bone marrow transplantation. Tested cells are injected into a mouse that has received a dose of irradiation sufficient to kill its own blood-producing cells. If the mouse recovers after that and all types of blood cells reappear, the transplanted cells are deemed to have included stem cells.