Answer to Question #91934 in Cell Biology for Tanzeela

Question #91934
why mature cell has less nuclear pores then immature cell?
1
Expert's answer
2019-07-24T05:17:59-0400

In eukaryotic cells, the nucleus is a complex and sophisticated organelle containing genomic DNA and supports essential cellular activities. Its surface contains many nuclear pore complexes (NPCs), channels for macromolecular transport between the cytoplasm and nucleus. It has been observed that the nuclear volume and the number of NPCs almost double during interphase in dividing cells. This is because Cyclin-dependent protein kinases (Cdks) control interphase NPC formation in dividing human cells as Cdk1 kinases that phosphorylate nucleoporins and open nuclear pores and also  Cdks drive the very early step of NPC formation and signals the cells that it is ready to pass into the next stage of cell cycle. Cdk inhibition suppressed the generation of “nascent pores,” which are considered to be immature NPCs, and disturbed expression and localization of some nucleoporins that causes open of nuclear pores in immature cells.

So nuclear pores in immature cells is more than that of mature cells.



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