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Answer to Question #68140 in Cell Biology for Del

Question #68140
When a cell synthesizes a protein, does it matter whether the mRNA comes from a maternal or a paternal allele of the gene that codes for the protein?
Expert's answer
When a cell synthesizes a protein, it matters whether the mRNA comes from a maternal or a paternal allele of the gene that codes for the protein.
This is because female mammals have an additional system for differential allele expression - ChrX inactivation. In a tissue, one ChrX is randomly inactivated by heterochromatisation. Therefore, most of the gene on one ChrX are off. That is why, some cells in a tissue will express the maternal allele, while others the parental allele.

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