Answer to Question #260424 in Cell Biology for hayrunisa

Question #260424

Which categories of amino acid would you expect to find on the surface of a soluble protein, and which would you expect to find in the interior? What distribution of amino acids would you expect to find in a protein embedded in a lipid bilayer?

Expert's answer


Amino acids are comprised of two functional groups; an amino group and a carboxyl group. When several amino acids combine with each other by an amine bond, they form protein. 


Amino acids that are polar in nature and have a charge will present on the surface of a soluble protein while those which do not have any charge and also non-polar in nature will be present on the interior of a protein. Amino acids with polar side chains are histidine, serine, asparagine, etc. Amino acids with nonpolar side chains are tryptophan, valine, alanine, etc.

In lipid bilayer, the nonpolar amino acids present on the surface of the protein while polar amino acids present the interior of a protein. 

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