Answer to Question #187091 in Cell Biology for saleh

Question

How describe the cAMP/PKA pathway?

Answer 1

The cAMP-dependent pathway is a G-protein-coupled receptor-activated signaling cascade used in cell communication. The activated G protein-coupled receptors in the cAMP-dependent pathway bind to adenylyl cyclase thus activating it. Activation of adenyl cyclase converts ATP to cAMP. An increase in cAMP results in the activation of protein kinase (PKA). PKA causes the conversion of glycogen to glucose, and it phosphorylates enzymes that facilitate muscle contraction in the heart leading to tachycardia. cAMP is also important in the maintenance of memory in the brain and absorption of water in the kidney.