Answer to Question #186251 in Cell Biology for mikle

Question #186251

describe the cAMP/PKA pathway?


1
Expert's answer
2021-04-29T04:29:48-0400

Explanation on cAMP/PKA pathway

In cAMP/PKA pathway, the first step is the epinephrine secretion by the adrenal glands, which then binds to a trimeric G-protein receptor on the plasma membrane, which induces a conformational change in the G-protein, causing the alpha subunit to release GDP and bind with GTP, activating the alpha subunit and causing it to dissociate from the beta and gamma subunit. The alpha subunit then binds to adenylyl cyclase, which converts ATP into cAMP. cAMP then binds to protein kinase A, which activates it. Protein kinase A then goes on to phosphorylate glycogen synthase a into glycogen synthase b, which inactivates it. PKA also phosphorylates phosphorylase kinase, which then phosphorylates phosphorylase b to phosphorylase a, which causes the breaking down on glycogen into glucose, which can be used in aerobic respiration to generate ATP.


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