Answer to Question #149596 in Cell Biology for rasp

Question #149596
Studies have noted an increase in the expression level of specific integrin proteins in tumor cells. Which type of integrins, those typically associated with hemi-desmosomes or those associated with focal adhesions, would you predict would confer an advantage in adopting the migratory behavior associated with metastasis? Briefly explain your reasoning.
1
Expert's answer
2020-12-10T11:24:25-0500

The type off integrins associated by this are the intracellular and the extracellular substrate .

They would adopt the migratory behavior associated by metastasis . This integrins enhances cell survival through several mechanisms . This integrins expressed in the tumor cells contributes to tumor progression and metastasis by increasing tumor cell migration , invasion proliferation and survival .

The integrins adhesion to the extracellular matrix provides the traction required for tumor cell invasion also regulating the localization and activity of matrix degrading protease . Also in result to cell motality .


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