Chromatin is the complex combination of DNA and proteins that makes up chromosomes. It is found inside the nuclei of eukaryotic cells. The functions of chromatin are: to package DNA into a smaller volume to fit in the cell. to strengthen the DNA to allow mitosis and meiosis.Definition. noun, plural: chromatins. A complex of nucleic acids (e.g. DNA or RNA) and proteins (e.g. histones), which condenses to form a chromosome during cell division. Supplement. A chromatin is a macromolecule made up of DNA or RNA and proteins. Chromatin is a mass of genetic material composed of DNA and proteins that condense to form chromosomes during eukaryotic cell division. Chromatin is located in the nucleus of our cells.