Answer to Question #195317 in Bioinformatics for Faye

Question #195317


1. For each seq:


a) Identify the protein and species


b) At approx what amino acid number is the most hydrophilic region


of the protein?


c) Do you expect it to be secreted? If so, by what mechanism?


d) List the motifs that are identified. Use the standard parameters for the tool


you choose to use.


Seq1


MQVNTFSNIASMARTQVSNKKADDAKENTKDKNVQSANSSKDVDKNTLEKLNALG


GKGITQIYLVQFQQQTMNAVIGSSNAQTGLDSLLNGANLDTAKSILTNIDFASLGYSS


KNPLDMNTDELQQLVSEDGFFGVENTANRIADFVIKGGGDDVEKLKKGLEGMKKG


FEQAEKMWGGELPQISQNTIDAALKKVSDRIDELGGKTLDLQA




Seq2


MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTR


REAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN




Seq3


MRLVILTLLIVGVFASNDDLWHQWKRIYNKEYKGADDDHRRNIWEQNVKHIQEHNL


RHDLGLVTYKLGLNQFTDMTFEEFKAKYLTEMPRASELLSHGIPYKANKRAVPDRID


WRESGYVTEVKDQGGCGSCWAFSTTGAMEGQYMKNEKTSISFSEQQLVDCSGP


FGNYGCNGGLMENAYEYLKRFGLETESSYPYRAVEGQCRYNEQLGVAKVTGYYT


VHSGDEVELQNLVGCRRPAAVALDVESDFMMYRSGIYQSQTCSPDRLNHGVLAV


GYGIQDGTDYWIVKNSWGTWWGEDGYIRMVRKRGNMCGIASLASVPMVAQFP




1
Expert's answer
2021-05-24T02:16:02-0400

Quaternary protein & Structural specie


Because the charged and polar amino acids are hydrophilic, they are usually found at the surface of a water-soluble protein, where they not only contribute to the solubility of the protein in water but also form binding sites for charged molecules.


No

The TATA promoter sequence is an example of a highly conserved DNA sequence motif found in eukaryotes. Another example of motifs: binding sites for transcription factors (TF) near promoter regions of genes, etc.



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