Answer to Question #154923 in Bioinformatics for vaibhav

Question

(a) Explain the role of guide trees in progressive multiple sequence alignment algorithms.

What do the leaf and internal nodes of a guide tree represent?

(b) Determine the sum-of-pairs scores for the following multiple sequence alignment of DNA sequences, using the scoring matrix in which a match gets a value of +4, a mismatch gets a value of -1, a (base,-) pair gets a value of -2, and a (-,-) pair gets a value of 0.

GCAA

GT - A

C - - A

Answer 1

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